Best Sandwich in America: Gulf Coast Pictures

Adam's first stop on his Gulf Coast tour is New Orleans. He heads to Domilise's for their famous shrimp po'boy.

Adam meets the Domilise clan. The restaurant has been in the family for several generations.

The building that is now Domilise's used to be a dry goods store.

Chef Mary Lou Borne prepares po'boy sandwiches.

It's the shrimp po'boy that Adam has come to taste. Does it have what it takes to be the best sandwich in America?

Adam checks out all the po'boys and can't wait to dig in!

Next, it is over to Tampa, FL, for some Cuban fare at Aguila Sandwich Shop.

Adam meets with chef and owner Mario Aguila. The Aguila family has been in the restaurant business for more than 20 years.

Chef and owner Mario Aguila prepares the shop's famous Media Noche sandwich.

Adam can't wait to take a bite of the Media Noche. The Aguila Sandwich Shop has perfected the creation that is a twist on the classic Cubano.

Will the Media Noche be crowned the Gulf Coast region champ?

The last stop on the Gulf Coast tour is Skipper's Smokehouse in Tampa, FL.

Adam is all smiles as he poses with Skipper's Smokehouse owners Tom White and Victoria Dodds -- and their infamous grouper Reuben.

Adam shows off his blackened grouper Reuben. His taste buds are just dying for a bite of the marble rye bread, grouper, melted Swiss cheese and warm sauerkraut.

It's a tough match-up among the shrimp po'boy, the Media Noche and the grouper Reuben, but only one can be crowned the regional champ. Tune in to find out which sandwich will take the title.