Forget about margaritas. Instead, sip some housemade Tempranillo at Hotel Endemico's poolside wine bar. One of the design-savvy, small hotels cropping up in Mexico's burgeoning wine region of Valle de Guadalupe, Hotel Endemico has 20 pod-style, luxury cabins. Nestling a hill, constructed of metal and wood, they meld into the rock-strewn, dusty landscape. Base here to explore the area's more than 50 wineries. Or relax on your porch, wineglass aloft, and gaze at mountain vistas.